Advertisements

Understanding the Neurological Link between Chronic Stress and Sleep Disturbances, and How Bright-Light Treatment Offers Relief

by Kaia

A recent study conducted at Jinan University in China has unveiled the neural pathway responsible for the connection between chronic stress and sleep disruptions. Additionally, the research elucidates how bright-light treatment effectively ameliorates these issues. The study, conducted on mouse models, underscores the pivotal role of the lateral habenula, a brain region sensitive to light signals, in influencing non-REM sleep patterns. Intriguingly, bright-light treatment was found to suppress specific neurons, mitigating stress-induced sleep abnormalities.

Advertisements

Key Facts:

Advertisements

Chronic stress can lead to an increase in non-REM sleep, a condition that can be effectively counteracted through bright-light treatment.
The lateral habenula, a brain region sensitive to light signals, plays a crucial role in mediating the impact of stress on sleep patterns.
Bright-light treatment operates by inhibiting the habenula-RMT neurons, thus reducing non-REM sleep abnormalities induced by stress.

Advertisements

Source: PLOS Biology

Advertisements

Chronic stress is a known precursor to sleep disturbances, and a recent study conducted by Lu Huang and a team of researchers from Jinan University in China has made significant strides in understanding the neural mechanisms underlying this phenomenon. Their findings also shed light on the effectiveness of bright-light treatment in mitigating these issues. Published on September 7th in the open-access journal PLOS Biology, this research utilized mouse models to investigate the intricate relationship between chronic stress, sleep patterns, and the lateral habenula—a brain region sensitive to light signals.

The researchers posited that the lateral habenula might play a crucial role in this process because it not only receives light signals from the eyes but also exerts influence over other brain regions responsible for regulating sleep.

To test this hypothesis and comprehensively unravel the neural pathway at play, the team conducted a series of chemogenetic and optogenetic studies on mouse models subjected to chronic stress, which often resulted in disrupted sleep patterns characterized by increased non-REM sleep. Remarkably, bright-light treatment was shown to effectively reverse these irregular sleep patterns.

As anticipated, the lateral habenula was found to be instrumental in modulating the effects of stress on sleep. Chemogenetic inhibition of the lateral habenula in stressed mice successfully prevented the excessive non-REM sleep, while its chronic activation in unstressed mice resulted in an increase in non-REM sleep.

Furthermore, by selectively activating habenular neurons that transmit signals to distinct brain regions, the researchers pinpointed the connection between the habenula and the rostromedial tegmental nucleus (RMT) as a critical factor. Activation of these specific neurons emulated the effects of stress on sleep, while inhibiting them in stressed mice mimicked the positive impact of bright-light treatment.

Lastly, the researchers elucidated that light-sensitive neurons located in the lateral geniculate nucleus (LGN) naturally inhibit the habenula-RMT neurons. This discovery explains why bright-light treatment effectively reduces stress-induced abnormalities in non-REM sleep.

This groundbreaking study not only provides valuable insights into the neurological mechanisms linking chronic stress to sleep disturbances but also underscores the therapeutic potential of bright-light treatment in addressing these issues. The findings offer hope for individuals grappling with stress-related sleep problems, paving the way for more targeted interventions in the future.

Advertisements

related articles

blank

Menhealthdomain is a men’s health portal. The main columns include Healthy Diet, Mental Health, Health Conditions, Sleep, Knowledge, News, etc.

【Contact us: [email protected]

Copyright © 2023 Menhealthdomain.com [ [email protected] ]